British Air Force Typhoon jets have joined forces with France's air force in a coordinated attack targeting an hidden munitions depot in Syrian territory operated by the IS group, according to the British defence ministry.
The location, located using surveillance, was thought to be storing arms and explosives, the statement said, and was situated in mountains just above Palmyra in Syria's central region.
"The RAF jets utilized precision-guided Paveway IV munitions to hit a several access tunnels providing entry to the facility... initial indications suggest the strike was effective," the MoD said.
There was no indication of any civilian impact in the attack conducted Saturday night and all the aircraft returned safely, the MoD added.
The Typhoon fighters were supported by a Voyager tanker plane.
The Islamic State group - referred to as ISIS - established extremist governance over parts of both Syria and Iraq prior to its 2019 collapse.
"This action shows British leadership, and determination to stand shoulder to shoulder with allied nations, to eradicate any revival of the terrorist group and their harmful and extremist ideologies in the Middle East," UK Defence Secretary the minister remarked.
British military aircraft have carried out overwatch operations over Syria to "prevent any attempted resurgence" of IS following its defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I want to thank every member of our armed forces who took part in this strike for their professionalism and their courage," the Defence Secretary said. "They were part of thousands of British troops deployed over Christmas and New Year. This mission, to remove dangerous terrorists who pose a risk to our security, demonstrates how our armed forces are ready to step up, continuously, ensuring Britain's security within its borders and influential overseas."
In December, the United States armed forces conducted what it termed a "large-scale strike" targeting IS targets in the country, following an assault resulted in the deaths of two US troops and a civilian interpreter in Palmyra.
The United Nations estimates Islamic State still has roughly 5-7 thousand combatants in Iraq and Syria.